Endogenous hormones matters in evaluation of endocrine disruptive effects mediated by nuclear receptors

作     者：Yanbin Zhao Karl Fent 

作者机构：State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging ContaminantsSchool of Environmental Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China ETH ZürichInstitute of Biogeochemistry and Pollution DynamicsDepartment of Environmental Systems ScienceCH-8092 ZürichSwitzerland 

出 版 物：《Eco-Environment & Health》 (生态环境与健康（英文）)

年 卷 期：2024年第3卷第3期

页      面：257-259页

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学] 

基　　金：supported by the National Natural Science Foundation of China(22122605) the National Key Research and Development Program of China(2022YFC3902100) 

主　　题：doubt confirmation identification 

摘      要：In recent decades,endocrine-disrupting chemicals(EDCs)have emerged as a prominent focus on environmental science and ***,extensive use of in vitro bioassays founded on ligand-receptor binding has facilitated the identification of a substantial number of potential EDCs,particularly agonists/antagonists of nuclear receptors such as estrogen receptors and thyroid hormone receptors[1].These datasets have significantly augmented the discovery of potential ***,when subjecting these compounds to in vivo exposures,spanning from teleost fish to rodents and humans,observations frequently deviated from in vitro anticipation[2,3].This discrepancy and the apparent lack of prognostic value are shared with the difficulties of in vitro-in vivo extrapolations in classical toxicological *** the utility of in vitro identification is without doubt,its potential EDCs require in vivo *** resulting complexity in EDCs outcomes,nevertheless,has not yet received adequate attention and thorough interpretation.