内镜下静脉曲张结扎术联合部分脾脏栓塞术:可明显改善伴有食管静脉曲张与血小板减少的肝硬化患者预后

作     者：Ohmoto K. Yoshioka N. Tomiyama Y. 王顺涛 

作者机构：Division of HepatologyDepartment of MedicineKawasaki Medical School577 MatsushimaKurashikiOkayama 701-0192Japan Dr. 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2006年第2卷第9期

页      面：12-13页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：内镜下静脉曲张结扎术 食管静脉曲张 肝硬化患者 血小板减少 脾脏栓塞术 曲张静脉出血 部分性脾栓塞术 EVL术 

摘      要：The aim of this study was to assess the efficacy of the combination of endoscopic variceal ligation(EVL)and partial splenic embolization(PSE)compared with EVL alone in cirrhosis patients with *** a prospective study,84 cirrhosis patients with esophageal varices and thrombocytopenia(platelet count 50,000/mm3)underwent EVL plus PSE(N = 42)or EVL alone(N = 42).Primary end points assessed during the follow-up period included the recurrence of varices,progression to variceal bleeding,and *** between combined treatment and variceal ligation alone by multivariate analysis showed a hazard ratio of 0.44 for the recurrence of varices(P = 0.02),0.19 for progression to variceal bleeding(P = 0.01),and 0.31 for death(P = 0.04).These results suggest that the combination of EVL plus PSE can prevent the recurrence of varices,progression to variceal bleeding,and death in cirrhosis patients with esophageal varices and thrombocytopenia.