Next Generation Nutrition: Genomic and Molecular Breeding Innovations for Iron and Zinc Biofortification in Rice

作     者：Kunhikrishnan Hemalatha DHANYALAKSHMI Reshma MOHAN Sasmita BEHERA Uday Chand JHA Debashis MOHARANA Ahalya BEHERA Sini THOMAS Preman Rejitha SOUMYA Rameswar Prasad SAH Radha BEENA Kunhikrishnan Hemalatha DHANYALAKSHMI;Reshma MOHAN;Sasmita BEHERA;Uday Chand JHA;Debashis MOHARANA;Ahalya BEHERA;Sini THOMAS;Preman Rejitha SOUMYA;Rameswar Prasad SAH;Radha BEENA

作者机构：Department of Plant PhysiologyCollege of AgriculturePadannakkadKerala Agricultural UniversityKerala 671314India Department of Plant PhysiologyCollege of AgricultureVellayaniKerala Agricultural UniversityKerala 695522India Crop Improvement DivisionIndia Council of Agricultural Research-National Rice Research InstituteOdisha 7530006India Department of Plant Breeding and GeneticsIndian Institute of Pulse ResearchKanpur 208024India Department of Plant PhysiologyCollege of AgricultureKumarakomKerala Agricultural UniversityKerala 686563India 

出 版 物：《Rice science》 (水稻科学（英文版）)

年 卷 期：2024年第31卷第5期

页      面：526-544,I0029,I0030页

核心收录：

学科分类：09[农学] 0901[农学-作物学] 

主　　题：biofortification grain quality iron phytic acid rice zinc 

摘      要：Global efforts to address malnutrition and hidden hunger, particularly prevalent in low- and middle-income countries, have intensified, with a focus on enhancing the nutritional content of staple crops like rice. Despite serving as a staple for over half of the world s population, rice falls short in meeting daily nutritional requirements, especially for iron(Fe) and zinc(Zn). Genetic resources, such as wild rice species and specific rice varieties, offer promising avenues for enhancing Fe and Zn content. Additionally, molecular breeding approaches have identified key genes and loci associated with Fe and Zn accumulation in rice grains. This review explores the genetic resources and molecular mechanisms underlying Fe and Zn accumulation in rice grains. The functional genomics involved in Fe uptake, transport, and distribution in rice plants have revealed key genes such as OsFRO1, OsIRT1, and OsNAS3. Similarly, genes associated with Zn uptake and translocation, including OsZIP11 and OsNRAMP1, have been identified. Transgenic approaches, leveraging transporter gene families and genome editing technologies, offer promising avenues for enhancing Fe and Zn content in rice grains. Moreover, strategies for reducing phytic acid(PA) content, a known inhibitor of mineral bioavailability, have been explored, including the identification of low-PA mutants and natural variants. The integration of genomic information, including whole-genome resequencing and pan-genome analyses, provides valuable insights into the genetic basis of micronutrient traits and facilitates targeted breeding efforts. Functional genomics studies have elucidated the molecular mechanisms underlying Fe uptake and translocation in rice. Furthermore, transgenic and genome editing techniques have shown promise in enhancing Fe and Zn content in rice grains through the manipulation of key transporter genes. Overall, the integration of multi-omics approaches holds significant promise for addressing global malnutri