Heterogeneity and clinical genomics of bla_(KPC-2)-producing,carbapenem-resistant Pseudomonas aeruginosa
作者机构：Key Laboratory of Multiple Organ FailureMinistry of EducationDepartments of Microbiology and General Intensive Care Unit of the Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic EngineeringZhejiangChina Cancer Center at IllinoisUniversity of Illinois at Urbana-ChampaignIllinoisUSA Department of BioengineeringUniversity of Illinois at Urbana-ChampaignIllinoisUSA
出 版 物：《hLife》 (健康科学（英文）)
年 卷 期：2024年第2卷第6期
页 面：314-319页
学科分类：100208[医学-临床检验诊断学] 1002[医学-临床医学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(32141001 and 31830001 to Y.F.) the National Science Fund for Distinguished Young Scholar(32125003 to Y.F.) the National Key Basic Research Program of China(2023YFC2307100 and 2023YFC2300021 to Y.F.)
摘 要：Antimicrobial resistance(AMR)is one of the top global challenges of public health *** 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infec***-resistant ***(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE*** is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 *** from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in ***,which compromises the clinical efficacy of the carbapenem as a“last resort***,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one healthconsisting of humans,animals,plants/crops,and environmental set*** addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.
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