Macleaya cordata extract exhibits some potential as a surrogate antibiotic by improving gastrointestinal epithelial status and humoral response in goats

作     者：Qiongxian Yan Xilin Li Xiaoling Zhou Wenxun Chen Xingzhou Tian Suntorn Wittayakun Pramote Paengkoum Zhiliang Tan Qiongxian Yan;Xilin Li;Xiaoling Zhou;Wenxun Chen;Xingzhou Tian;Suntorn Wittayakun;Pramote Paengkoum;Zhiliang Tan

作者机构：Chinese Academy of Sciences Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionHunan Provincial Key Laboratory of Animal Nutrition&Physiology and MetabolismInstitute of Subtropical AgricultureThe Chinese Academy of SciencesChangsha 410125China College of Animal ScienceTarim UniversityAlaer 843300China Key Laboratory of Animal GeneticsBreeding and Reproduction in the Plateau Mountainous RegionMinistry of EducationCollege of Animal ScienceGuizhou UniversityGuiyang 550025China Faculty of Science and Agricultural TechnologyRajamangala University of Technology LannaLampang 52000Thailand School of Animal Technology and InnovationInstitute of Agricultural TechnologySuranaree University of TechnologyNakhon Ratchasima 30000Thailand 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2024年第18卷第3期

页      面：356-366页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by National Key R&D Program of China (2022YFD1301700) Changsha Munic-ipal Natural Science Foundation (kq2208245) Strategic Priority Research Program of the Chinese Academy of Sciences (XDA26040304) Natural Science Foundation of Hunan Province of China (2022JJ10054) 

主　　题：Macleaya cordata extract Substitution of antibiotics Humoral immunity Gastrointestinal health Bacterial community Branch-chain fatty acid 

摘      要：Macleaya cordata extract(MCE)is a potential replacement for *** the current study,effects of MCE on the gastrointestinal health and humoral responses of host animals were explored.A total of 30 weanling goats with similar body weight of 9.15±1.36 kg were randomly allocated into three groups(n=10 per group):control group(CON group,fed with a basal diet),antibiotic group(Abx group,fed with the basal diet supplemented with 0.18 g/d vancomycin and 0.36 g/d neomycin),and MCE group(fed with the basal diet supplemented with 5 g/d MCE),for three *** showed that antibiotic addition decreased the height and area of rumen papillae,ruminal mucosa Toll-like receptor 8(TLR8),interleukin-8(IL-8)and interleukin-1β(IL-1β)gene relative expression levels and microbial diversity,altered the volatile fatty acid(VFA)profile in the rumen,and increased monocytes amount and CD4^(+)T cells percentage in the peripheral blood(P0.05)compared to CON *** addition increased the average daily gain,ileal villus height,villus height/crypt depth,and immunoglobulin M(IgM)content in the peripheral blood(P0.05)compared to the ***,MCE addition decreased the proportion of isobutyric acid in the chyme of the ileum(P=0.005)compared to the CON *** results suggest that antibiotic supplementation may suppress the epithelial state and microbial diversity and fermentation in goats,but stimulate cellular response to maintain the growth performance of *** administration improved the epithelial state and humoral response to promote the growth performance in goats.