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Repressors of reprogramming

Repressors of reprogramming

作     者:Melissa Popowski Haley Tucker 

作者机构:the Rockefeller University New York Institute for Cellular and Molecular BiologyUniversity of Texas at Austin 

出 版 物:《World Journal of Stem Cells》 (世界干细胞杂志(英文版)(电子版))

年 卷 期:2015年第7卷第3期

页      面:541-546页

核心收录:

学科分类:1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主  题:Reprogramming Induced pluripotency Stem cells 

摘      要:Induced pluripotent stem cells(i PSCs) have been the focal point of ever increasing interest and scrutiny as they hold the promise of personalized regenerative medicine. However, creation of i PSCs is an inefficient process that requires forced expression of potentially oncogenic proteins. In order to unlock the full potential of i PSCs, both for basic and clinical research, we must broaden our search for more reliable ways of inducing pluripotency in somatic cells. This review surveys an area of reprogramming that does not receive as much focus, barriers to reprogramming, in the hope of stimulating new ideas and approaches towardsdeveloping safer and more efficient methods of reprogramming. Better methods of i PSC creation will allow for more reliable disease modeling, better basic research into the pluripotent state and safer i PSCs that can be used in a clinical setting.

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