Neurotoxicity of cancer chemotherapy

作     者：Miyoung Yang Changjong Moon 

作者机构：Department of Veterinary Anatomy College of Veterinary Medicine and Animal Medical Institute Chonnam National University Department of Physiology and Neuroscience Program Michigan State University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第17期

页      面：1606-1614页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by a National Research Foundation of Korea Grant funded by the Korean Government, No. NRF-2011-0003380 2012R1A1B44001262 a grant from Animal Medical Institute of Chonnam National University 

主　　题：neural regeneration reviews neurogenesis behavioral dysfunction chemotherapy hippocampaldysfunction memory deficit mood disorder neurodegeneration neuron neuroplasticity neurotoxicity grants-supported paper neuroregeneration 

摘      要：There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causa mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.