Physicochemical Properties and Evaluation of Microemulsion Systems for Transdermal Delivery of Meloxicam

作     者：YUAN Yue LI San-ruing YU Li-min DENG Pan ZHONG Da-fang 

作者机构：School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 P. R. China Center for Drug Metabolism and Pharmacokinetics ResearchShanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第1期

页      面：81-86页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by of the "863" Program of China(No 2003AA2Z347C) 

主　　题：Microemulsion Physicochemical property Transdermal delivery Meloxicam Polyoxyethylene sorbitan triolcate 

摘      要：Microemulsion systems, composed of water, isopropyl myristate （IPM）, polyoxyethylene sorbitan trioleate （Tween 85 ）, and ethanol, were investigated as transdermal drug delivery vehicles for a lipophilic model drug（ meloxicam）. The purpose of this study was to investigate the physicochemieal properties of the tested microemulsion and to find the correlation between the physicoehemical properties and the skin permeation rate of the microemulsion. Pseudo-ternary phase diagram of the investigated system at a constant surfactant/cosurfactant mass ratio （ Km = 1 ： 1 ） was constructed by titration at 20℃, and the five fommlations were selected for further research in the o/w microemulsion domains. The values of electrical conductivity and viscosity showed that the selected systems were bicontinuous or non-spherical o/w microemulsion, and the electrical conductivity and viscosity were increased with increasing the content of water. These results suggest that the optimum formulation of microemulsion, containing 0. 375 meloxicam, 5% isopropyl myristate, 25% Tween 85. 25% ethanol, and water, showed the maximum permeation rate. It had a high electrical conductivity, small droplet size, and proper viscocity.