Progress in investigating the pathogenesis of hepatopulmonary syndrome

作     者：Zhang, Zhao-Jie Yang, Chang-Qing 

作者机构：Tongji Univ Sch Med Tongji Hosp Div Gastroenterol Shanghai 200065 Peoples R China Tongji Univ Sch Med Tongji Hosp Inst Digest Dis Shanghai 200065 Peoples R China 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2010年第9卷第4期

页      面：355-360页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Shanghai International Co-operation Program Shanghai Excellent Academic Leaders Program [08XD14045] 

主　　题：hepatopulmonary syndrome cirrhosis pathogenesis angiogenesis intestinal endotoxemia nitric oxide carbon monoxide 

摘      要：BACKGROUND: The pathogenesis of hepatopulmonary syndrome is complicated and remains unknown. This review aims to provide an updated knowledge about the pathogenesis of the syndrome. DATA SOURCES: Five medical databases, MEDLINE, Science-Direct, OVID, Springer Link, and Wiley Inter Science were searched for articles on hepatopulmonary syndrome , cirrhosis , angiogenesis , intestinal endotoxemia , nitric oxide , carbon monoxide , and other related subjects. RESULTS: Currently, imbalance between vasodilation and vasoconstriction, intestinal bacterial translocation, intestinal endotoxemia, and activation of the lung monocyte/macrophage system may play important roles in the pathogenesis of hepatopulmonary syndrome. Recent studies found that angiogenesis is also an important factor in the pathogenesis of experimental hepatopulmonary syndrome. CONCLUSION: Angiogenesis inhibition may be a potential approach for the treatment of hepatopulmonary syndrome in the future.