Computed tomography overestimation of esophageal tumor length: Implications for radiotherapy planning

作     者：Karim Sillah Luke R Williams Hans-Ulrich Laasch Azeem Saleem Gillian Watkins Susan A Pritchard Patricia M Price Catharine M West Ian M Welch 

作者机构：Department of Gastrointestinal SurgeryUniversity Hospital of South Manchester NHS Foundation TrustSouthmoor RoadManchester M23 9LTUnited Kingdom School of Cancer&Enabling SciencesUniversity of ManchesterChristie HospitalWilmslow RoadManchester M20 4BXUnited Kingdom Department of RadiologyUniversity Hospital of South Manchester NHS Foundation TrustSouthmoor RoadManchester M23 9LTUnited Kingdom Department of RadiologyThe Christie NHS Foundation TrustWilmslow RoadManchester M20 4BXUnited Kingdom Department of HistopathologyUniversity Hospital of South Manchester NHS Foundation TrustSouthmoor RoadManchester M23 9LTUnited Kingdom 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2010年第2卷第4期

页      面：197-204页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by The local departmental research fund 

主　　题：Computed tomography Esophageal cancer Radiotherapy 

摘      要：AIM:To assess the relationship between preoperative computed tomography(CT)and postoperative pathological measurements of esophageal tumor length and the prognostic significance of CT tumor length ***:A retrospective study was carried out in 56 patients who underwent curative *** lengths were measured on the immediate preoperative CT and on the post-operative resection ***-and intra-observer variations in CT measurements were *** data were ***:There was a weak correlation between CT and pathological tumor length(r=0.30,P=0.025).CT lengths were longer than pathological lengths in 68%(38/56)of patients with a mean difference of 1.67 cm(95%CI:1.18-2.97).The mean difference in measurements by two radiologists was 0.39 cm(95% CI:-0.59-1.44).The mean difference between repeat CT measured tumor length(intra-observer variation) were 0.04 cm(95%CI:-0.59-0.66)and 0.47 cm (95%CI:-0.53-1.47).When stratified,patients not receiving neoadjuvant chemotherapy showed a strong correlation between CT and pathological tumor length(r =0.69,P=0.0014,n=37)than patients that did(r= 0.13,P=0.43,n=19).Median survival with CT tumor length5.6 cm was poorer than with smaller tumors,but the difference was not statistically ***:Esophageal tumor length assessed using CT does not reflect pathological tumor extent and should not be the only modality used for management decisions,particularly for planning radiotherapy.