Quantitative differences in protein expression between cisplatin sensitive COC1 ovarian carcinoma cells and cisplatin resistant COC1/DDP cells
Quantitative differences in protein expression between cisplatin sensitive COC1 ovarian carcinoma cells and cisplatin resistant COC1/DDP cells作者机构：Department of Obstetrics and Gynecology Second HospitalTsinghua University Beijing 100049 China Department of General Surgery Second Hospital China MedicalUniversity Shenyang Liaoning 110001 China Department of Obstetrics and Gynecology Second Hospital JilinUniversity Changchun Jilin 130041 China Department of Obstetrics and Gynecology Beijing Obstetrics andGynecology Hospital Capital Medical University Beijing 100026China
出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)
年 卷 期：2009年第122卷第7期
页 面：865-869页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：chemoresistance ovarian cancer proteomics molecular markers gel electrophoresis
摘 要：Ovarian cancer is the second most common cancer of the reproductive system in women and is the leading cause of death from gynecological cancers. Despite good response to surgery and initial chemotherapy, the resistance to platinum in some ovarian cancers represents a major obstacle to successful therapy. A number of mechanisms for ovarian cancer platinum resistance have been reported. These mechanisms include the reduction of cisplatin accumulation within cancer cells, the ability to detoxify cisplatin, faster repair of cisplatin-DNA adducts, modulation of apoptotic pathways, up-regulation of transcription factors, and a higher concentration of glutathione and metallothioneins.
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