Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment

作     者：Qihang Wu Hui Wen Wenhai Lin Tingting Sun Zhigang Xie 

作者机构：State Key Laboratory of Polymer Physics and ChemistryChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Biomedical Polymers LaboratoryCollege of ChemistryChemical Engineering and Materials Scienceand State Key Laboratory of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第12期

页      面：546-549页

核心收录：

学科分类：081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financial support from the National Natural Science Foundation of China(Nos.52003267 and51973214) 

主　　题：BODIPY Alkyl chain engineering Photodynamic therapy Antibacterial agent Photosensitizer 

摘      要：Photodynamic therapy has been widely employed as an alternative strategy against bacterial *** structure has a profound effect on the antibacterial ability of photosensitizers(PSs).Herein,we designed and synthesized a series of boron dipyrromethene(BODIPY)-based photosensitizers with different alkyl chain lengths,and then their antibacterial activities were *** these BODIPYs,the BODIPY with octyl(BDP-8)exhibits the best antibacterial effect,while the antibacterial performance of BODIPY with dodecyl(BDP-12)is the *** work provides instructive information for further development of effective photodynamic antimicrobial agents.