Polymorphism of apolipoprotein E gene and post-stroke vascular dementia

作     者：Xinjing Lin Changlin Hu Yunlan Xie Xin Zhang Xiangping Liu Ge Yan 

作者机构：Department of Neurology Second Affiliated Hospital of Chongqing University of Medical Sciences Chongqing 400010 China Shandong Institute for the Prevention and Cure of Parasitic Diseases Jining 272033 Shandong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2006年第1卷第5期

页      面：462-464页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：vascular dementia apolipoprotein E Cerebrovascular Disease Medical Sciences average age Mental Disorders allele frequency genetic factors venous blood 

摘      要：BACKGROUNO： Studies have indicated that the more certain etiological factors of vascular dementia are the sites, size and number of cerebrovascular lesions, but there are arguments all the time in the relationship of genetic factors, especially apolipoprotein E gene, with the occurrence and development of vascular dementia. OBJECTIVE： To analyze the relationship between the polymorphism of apolipoprotein E gene and vascular dementia in stroke patients. OESIGN ： A non-randomized grouped comparative observation at the same time SETTING ： The Laboratory of Neurology, the Second Affiliated Hospital of Chongqing University of Medical Sciences. PARTICIPANTS： Totally 121 inpatients with stroke were selected from the Department of Neurology, the Second Affiliated Hospital of Chongqing University of Medical Sciences from January 2000 to December 2001. All the patients were accorded with the diagnostic standards for cerebrovascular diseases set by the Second National Academic Meeting for Cerebrovascular Disease, and confirmed by cranial CT or MRI. According to with vascular dementia or not, they were divided into vascular dementia group （n =58） and non-vascular dementia group （n =63）. In the vascular dementia group, there were 37 males and 21 females, the average age was （59＋8） years. They were all in accordance with the standard of the third edition of Diagnostic and Statistical Manual of Mental Disorders （DMS-Ⅲ）, without conscious disturbance and language disorder; hospitalized within 3 days after the attack of cerebrovascular disease. In the non-vascular dementia group, there were 37 males and 26 females, the average age was （59±9.5） years. They all had no intellectual disturbance within 3 months after the attack of cerebrovascular disease. All the subjects agreed to supply blood samples for the experiment. METHOOS： ①Fasting venous blood （2 mL） was drawn from each patient in the morning to extract DNA. The frequencies of apolipoprotein E genotypes and alleles were