Wastewater Surveillance Provides Spatiotemporal SARS-CoV-2 Infection Dynamics

作     者：Xiawan Zheng Kathy Leung Xiaoqing Xu Yu Deng Yulin Zhang Xi Chen Chung In Yau Kenny W.K.Hui Eddie Pak Ho-Kwong Chui Ron Yang Hein Min Tun Gabriel Matthew Leung Joseph Tsz Kei Wu Malik Peiris Leo Lit Man Poon Tong Zhang Xiawan Zheng;Kathy Leung;Xiaoqing Xu;Yu Deng;Yulin Zhang;Xi Chen;Chung In Yau;Kenny W.K.Hui;Eddie Pak;Ho-Kwong Chui;Ron Yang;Hein Min Tun;Gabriel Matthew Leung;Joseph Tsz Kei Wu;Malik Peiris;Leo Lit Man Poon;Tong Zhang

作者机构：Environmental Microbiome Engineering and Biotechnology LabCenter for Environmental Engineering ResearchDepartment of Civil EngineeringThe University of Hong KongHong Kong 999077China WHO Collaborating Centre for Infectious Disease Epidemiology and ControlSchool of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Laboratory of Data Discovery for Health Litd.(D24H)Hong Kong 999077China The University of Hong Kong-Shenzhen HospitalHong Kong 999077China School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China HKU-Pasteur Research PoleThe University of Hong KongHong Kong 999077China Drainage Services DepartmentThe Government of the Hong Kong Special Administrative RegionHong Kong 999077China Environmental Protection DepartmentThe Government of the Hong Kong Special Administrative RegionHong Kong 999077China The Jockey Club School of Public Health and Primary CareFaculty of MedicineThe University of Hong KongHong Kong 999077China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2024年第40卷第9期

页      面：70-77页

核心收录：

学科分类：082803[工学-农业生物环境与能源工程] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 08[工学] 0828[工学-农业工程] 0804[工学-仪器科学与技术] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：financially supported by the Health and Medical Research Fund(COVID1903015) the Food and Health Bureau,the Government of the Hong Kong Special Administrative Region(SAR),China supported by the AIR@InnoHK(KL,GML,and JTW) Health@InnoHK(MP and LLMP)administered by the Innovation and Technology Commission of the Government of the Hong Kong SAR 

主　　题：SARS-CoV-2 Wastewater surveillance Prevalence Effective reproductive number 

摘      要：Wastewater surveillance(WWS)can leverage its wide coverage,population-based sampling,and high monitoring frequency to capture citywide pandemic trends independent of clinical *** we conducted a nine months daily WWS for severe acute respiratory syndrome coronavirus 2(SARSCoV-2)from 12 wastewater treatment plants(WWTPs),covering approximately 80%of the population,to monitor infection dynamics in Hong Kong,*** found that the SARS-CoV-2 virus concentration in wastewater was correlated with the daily number of reported cases and reached two pandemic peaks three days earlier during the study *** addition,two different methods were established to estimate the prevalence/incidence rates from wastewater *** estimated results from wastewater were consistent with findings from two independent citywide clinical surveillance programmes(rapid antigen test(RAT)surveillance and serology surveillance),but higher than the cases number reported by the Centre for Health Protection(CHP)of Hong Kong,***,the effective reproductive number(R_(t))was estimated from wastewater measurements to reflect both citywide and regional transmission *** findings demonstrate that large-scale intensive WWS from WWTPs provides cost-effective and timely public health information,especially when the clinical surveillance is inadequate and *** approach also provides insights into pandemic dynamics at higher spatiotemporal resolutions,facilitating the formulation of effective control policies and targeted resource allocation.