Impact of liver diseases on the development of type 2 diabetes mellitus

作     者：Po-Shiuan Hsieh Yen-Ju Hsieh 

作者机构：Department of Physiology and Biophysics National Defense Medical Center Department of Medical Research Tri-Service General Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第48期

页      面：5240-5245页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The National Science Council, No. NSC98-2320-B-016-011 MY3T Tri-Service General Hospital, No. TSGH-C100-011-015-S03 

主　　题：Hepatic inflammation Insulin resistance βcell dysfunction Type 2 diabetes mellitus 

摘      要：The prevalence of type 2 diabetes mellitus （T2DM） is higher in patients who have liver diseases such as nonalcoholic fatty liver disease, chronic viral hepatitis, hemochromatosis, alcoholic liver disease and cirrhosis. It is suggested that there is a pathogenic link between the presence of T2DM and the severity of liver injury. However, evidence related to the impact of hepatic inflammation on the development of T2DM has not yet emerged. This article provides an overview of the evidence for an increased prevalence of diabetes in a range of liver diseases, the impact of liver diseases on insulin resistance and 13 cell dysfunction, and the potential mechanisms whereby coexistent liver diseases exacerbate the development of T2DM.