Diffusion MRI studies of experimental animal models and patients with stroke

作     者：Zheng Guang Chen, Tieqiang Li and Tomas Hindmarsh 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：1999年第2期

页      面：81-86页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：MRI studies experimental animal models Diffusion and 

摘      要：Abstract Purpose This overview summarises the diffusion magnetic resonance imaging (MRI) results both from the experimental animal model studies and clinical investigations in acute cerebral ischemic *** Sources An English literature searched using MEDLINE (1990-1997).Study Selection Over 80 papers and reviews published in the last eight years and our partial results were *** and Conclusions Diffusion weighted magnetic resonance imaging (DWI) has been extensively used to study acute cerebral ischemia both in experimental animal models and in patients. DWI yields signal intensity contrast modulated by water molecular self diffusion. By recording a series of DWI with different amplitudes of the displacement encoding gradient, the apparent diffusion coefficient (ADC) can be quantitatively mapped. DWI combined with quantitative ADC mapping can provide earlier and more precise evaluation of the ischemic zones. However, the biophysical mechanisms behind the decreased ADC in acute cerebral ischemia are still not fully understood.