Research advances of tetrahedral framework nucleic acid-based systems in biomedicine

作     者：Lihang Wang Mary Li Javier Chunshan Luo Tingsheng Lu Shudan Yao Bing Qiu Yun Wang Yunfeng Lin Lihang Wang;Mary Li Javier;Chunshan Luo;Tingsheng Lu;Shudan Yao;Bing Qiu;Yun Wang;Yunfeng Lin

作者机构：Department of Spine SurgeryBeijing Jishuitan Hospital Guizhou HospitalGuiyang 550014China State Key Laboratory of Oral DiseasesNational Center for StomatologyNational Clinical Research Centre for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu 610041China Sichuan Provincial Engineering Research Center of Oral BiomaterialsChengdu 610041China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第11期

页      面：35-43页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by National Key R&D Program of China(No.2019YFA0110600) National Natural Science Foundation of China(Nos.82370929,81970916) Sichuan Science and Technology Program(No.2022NSFSC0002) Sichuan Province Youth Science and Technology Innovation Team(No.2022JDTD0021) Research and Develop Program,West China Hospital of Stomatology Sichuan University(No.RD03202302) Science and technology support plan project of Guizhou Provincial Department of science and technology(No.Qiankehe supportGeneral264) 

主　　题：DNA nanomaterials Tetrahedral framework nucleic acid Drug delivery Antioxidation Immunomodulation Tissue regeneration Antitumor therapy 

摘      要：This article reviews the latest research advances of tetrahedral framework nucleic acid(t FNA)-based systems in their fabrication,modification,and the potential applications in *** arises from the synthesis of four single-stranded DNA *** chain contains brief sequences that complement those found in the other three,culminating in the creation of a pyramid-shaped nanostructure of approximately 10 nanometers in *** first generation of t FNA demonstrates inherent compatibility with biological systems and the ability to permeate cell membrane *** attributes translate into remarkable capabilities for regulating various cellular biological processes,fostering tissue regeneration,and modulating immune *** subsequent evolution of t FNA introduces enhanced adaptability and a relatively higher degree of biological *** advancement encompasses structural modifications,such as the addition of functional domains at the vertices or side arms,integration of low molecular weight pharmaceuticals,and the implementation of diverse strategies aimed at reversing multi-drug resistance in tumor cells or *** augmentations empower t FNA-based systems to be utilized in different scenarios,thus broadening their potential applications in various biomedical fields.