Precise and efficient insertion of A673T mutation in APP gene using MSYM

作     者：Qing Xia Zijie Liu Xinyu Yang Jiaying Xiao Xue Zhao Yu Zhao Feifei Zheng Fangliang Ge Ke Ye Lulu Liu Dayong Wang Xu Gao 

作者机构：Department of Biochemistry and Molecular BiologyHarbin Medical UniversityHarbinHeilongjiang 150000China Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Basic Medical InstituteHeilongjiang Medical Science AcademyHarbinHeilongjiang150000China Translational Medicine Center of Northern ChinaHarbinHeilongjiang 150000China Key Laboratory of Heilongjiang Province for Genetically Modified AnimalsHarbin Medical UniversityHarbinHeilongjiang 150000China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第6期

页      面：65-68页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Natural Science Foundation of China (No.81701078) the Natural Science Foundation of Heilongjiang Province of China (Outstanding Youth Foundation,No.YQ2022H003) China Postdoctoral Science Foundation (No.2016M600261,2018T110317) Heilongjiang Postdoctoral Financial Assistance (China) (No.LBH-Z15163) Heilongjiang Touyan Innovation Team Program (China) 

主　　题：protective Alzheimer impairment 

摘      要：Alzheimer s disease(AD)is a progressive neurodegenerative disorder causing memory loss,cognitive decline,language impairment,and disorientation,which impose an enormous burden on caregivers and the public health sector.A673T as a protective mutation has great therapeutic potential in AD.1,2 Therefore,a combination of stem cell therapy and A673T mutation existing in natural people based on gene targeting techniques such as CRISPR-Cas9 have been suggested as promising and exciting new developments.