Prophylactic Pattern Scanning Laser Retinal Photocoagulation for Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats: Preliminary Experimental Results

作     者：Rina Takagi Yoshiaki Tanaka Tetsuya Hasegawa Masami Shinohara Yasushi Kageyama Tomohiko Sasase Machiko Shimmura-Tomita Akihiro Kakehashi Toshikatsu Kaburaki Rina Takagi;Yoshiaki Tanaka;Tetsuya Hasegawa;Masami Shinohara;Yasushi Kageyama;Tomohiko Sasase;Machiko Shimmura-Tomita;Akihiro Kakehashi;Toshikatsu Kaburaki

作者机构：Department of Ophthalmology Saitama Medical Center Jichi Medical University Saitama-shi Saitama-ken Japan Tokyo Animal & Diet Department CLEA Japan Inc. Tokyo Japan Biological/Pharmacological Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc. Takatsuki Osaka Japan 

出 版 物：《Journal of Diabetes Mellitus》 (糖尿病（英文）)

年 卷 期：2024年第14卷第3期

页      面：153-165页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Diabetes Pattern Scanning Laser Diabetic Retinopathy Spontaneously Diabetic Torii Fatty Rats Electroretinography 

摘      要：Research Background and Purpose: The number of diabetic patients is rapidly increasing, making it crucial to find methods to prevent diabetic retinopathy (DR), a leading cause of blindness. We investigated the effects of prophylactic pattern scanning laser retinal photocoagulation on DR development in Spontaneously Diabetic Torii (SDT) fatty rats as a new prevention approach. Methods: Photocoagulation was applied to the right eyes of 8-week-old Spontaneously Diabetic Torii (SDT) fatty rats, with the left eyes serving as untreated controls. Electroretinography at 9 and 39 weeks of age and pathological examinations, including immunohistochemistry for vascular endothelial growth factor and glial fibrillary acidic protein at 24 and 40 weeks of age, were performed on both eyes. Results: There were no significant differences in amplitude and prolongation of the OP waves between the right and left eyes in SDT fatty rats at 39 weeks of age. Similarly, no significant differences in pathology and immunohistochemistry were observed between the right and left eyes in SDT fatty rats at 24 and 40 weeks of age. Conclusion: Prophylactic pattern scanning retinal laser photocoagulation did not affect the development of diabetic retinopathy in SDT fatty rats.