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Treatment Resistant Depression, Ketamine versus ECT

Treatment Resistant Depression, Ketamine versus ECT

作     者:Smita Agarkar Smita Agarkar

作者机构:Gracie Square Hospital New York USA Clinical Psychiatry Weill Cornell Medicine New York USA 

出 版 物:《Open Journal of Psychiatry》 (精神病学期刊(英文))

年 卷 期:2024年第14卷第4期

页      面:380-385页

学科分类:1002[医学-临床医学] 10[医学] 

主  题:Treatment Resistant Depression Ketamine ECT 

摘      要:Recent studies have highlighted the increase in treatment resistant depression. Of particular concern is the rising trend of depression and suicide rates among Young Adults. Ketamine was approved for treatment resistant depression in 2019 by the US Food and Drug Administration. It received an additional indication for treatment of suicidality. While intranasal Ketamine is approved for depression, recent data about intravenous infusion of Ketamine in controlled inpatient settings has been promising. ECT has a long-standing trend for being used for resistant depression and recent comparison trials have revealed positive results when head-to-head comparisons are made with Ketamine. Future studies need to focus on patient selection and wherein treatment algorithm should Ketamine be selected as treatment modality.

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