Liver transplantation in acute alcoholic hepatitis:Current status and future development

作     者：Ashwani K Singal Andrea Duchini 

作者机构：Division of Gastroenterology and HepatologyMayo ClinicRochesterMN 55905-0001United States 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2011年第3卷第8期

页      面：215-218页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Alcoholic hepatitis Liver transplantation Recidivism Alcohol abstinence 

摘      要：Acute alcoholic hepatitis (AH) is a distinct clinical entity amongst patients with chronic alcohol *** with severe AH are at risk of dying in about 20%-25% cases despite specific treatment with corticosteroids and/or ***,a need for an additional more effective treatment option is unmet *** transplantation (LT),a definitive treatment option for alcoholic cirrhosis requires 6 mo ***,this rule cannot be applied to patients with AH as these patients are actively drinking prior to their *** of donors,ethical issues,and fear of recidivism after transplantation with less than 6 mo pretransplant abstinence are some of the reasons behind this rule of 6 mo of abstinence and hesitancy of transplanting patients with *** issues are debated at length in this ***,retrospective studies have shown that patients undergoing transplantation for alcoholic cirrhosis and having histological changes of AH have been shown to fare as well when compared to patients without these histological ***,French workers have reported a case matched prospective study showing encouraging data on the usefulness of LT for patients who are non-responders to cortico-steroid and/or pentoxifylline *** studies are needed to identify patients with severe AH who are going to benefit most with *** the light of emerging data on the efficacy of LT in improving survival of patients with severe acute AH who do not respond to corticosteroids,the time is ripe to re-evaluate our policy of LT in patients with AH.