Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring

作     者：TANG Wei CHENG Jin Ping YANG Yi Chen WANG Wen Hua 

作者机构：School of Environmental Science and EngineeringShanghai Jiao Tong University 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2015年第28卷第9期

页      面：687-690页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.21177087) 

主　　题：PND Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring GSH LPO SOD 

摘      要：To assess the neurotoxic effects and redoxresponses of Aroclor 1254 （A1254） on perinatallyexposed rat offspring, A1254 was administered bygavage from gestational day （GD） 6 to postnatal day（PND） 21. Neurobehavioral development,antioxidant enzyme activities, lipid peroxidation（LPO）, nitric oxide （NO）, and NO synthase （NOS）levels were analyzed in the *** development analysis revealeddelayed appearance of the righting reflex, negativegeotaxis, and cliff drop test responses in A1254exposed group. Developmental A1254 exposurealso caused oxidative stress in the brain of PND 22offspring via reductions in the activity of SOD andGSH-Px, and by promoting a rise in the levels of NOand NOS.