Tumor angiogenesis and anti-angiogenic therapy
Tumor angiogenesis and anti-angiogenic therapy作者机构：Department of Pancreatic Surgery West China Hospital Sichuan University Chengdu Sichuan China Department of Microbiology Tumor and Cell Biology Karolinska Institute Stockholm Sweden Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine Vison and Brain Health) School of Pharmaceutical Science Wenzhou Medical University Wenzhou Zhejiang China Cancer Institute the First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu China Department of Cellular and Genetic Medicine School of Basic Medical Sciences Fudan University Shanghai China
出 版 物：《中华医学杂志(英文版)》 (Chinese Medical Journal)
年 卷 期：2024年第137卷第17期
页 面：2024 Jul 25页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：European Research Council (ERC) advanced grant ANGIOFAT(No. 250021) Swedish Research Council(Nos. 2021-06122, 2020-06121, 2020-03427, and 2019-01502) Swedish Cancer Foundation(Nos. 200734, 232684) Karolinska Institute Foundation(Nos. 2020-02080, 2018-00904) Karolinska Institute distinguished professor award, the NOVO Nordisk Foundation-Advance grant, the NOVO Nordisk Foundation(Nos. 0078219, 0057158) National Key Research & Development Program of China(No. 2020YFC0846600) Hong Kong Centre for Cerebro-cardiovascular Health Engineering, the National Natural Science Foundation of China and the Swedish Research Council Cooperative Research Project(No. 8211101233) Horizon Europe grant-PERSEUS(No. 101099423)
主 题：Angiogenesis Cancer Angiogenesis inhibitors Angiogenic factors Vascular endothelial growth factors Cancer therapy Combined modality therapy
摘 要：Anti-angiogenic drugs (AADs), which mainly target the vascular endothelial growth factor-A signaling pathway, have become a therapeutic option for cancer patients for two decades. During this period, tremendous clinical experience of anti-angiogenic therapy has been acquired, new AADs have been developed, and the clinical indications for AAD treatment of various cancers have been expanded using monotherapy and combination therapy. However, improvements in the therapeutic outcomes of clinically available AADs and the development of more effective next-generation AADs are still urgently required. This review aims to provide historical and perspective views on tumor angiogenesis to allow readers to gain mechanistic insights and learn new therapeutic development. We revisit the history of concept initiation and AAD discovery, and summarize the up-to-date clinical translation of anti-angiogenic cancer therapy in this field.
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