Peroral endoscopic myotomy for achalasia in patients aged ≥ 65 years

作     者：Chen-Jie Li Yu-Yong Tan Xue-Hong Wang De-Liang Liu 

作者机构：Department of Gastroenterologythe Second Xiangya Hospital of Central South University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第30期

页      面：9175-9181页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Achalasia Peroral endoscopic myotomy elderly Efficacy Quality of life 

摘      要：AIM:To investigate the safety and efficacy of peroral endoscopic myotomy(POEM) for achalasia in patients aged ≥ 65 ***:From November 2011 to August 2014,15 consecutive patients(aged ≥ 65 years) diagnosed with achalasia were prospectively recruited and all underwent POEM at our institution. Eckardt score,lower esophageal sphincter(LES) pressure,esophageal diameter,SF-36 questionnaire,and procedure-related complications were used to evaluate the ***:All 15 patients were treated successfully by POEM,with a median operation time of 55 min. Median myotomy length was 10 cm. Three patients underwent circular myotomy and 12 full-thickness myotomies. Symptoms remitted in all cases during post-POEM f o l l o w- u p o f 6- 3 9 m o. E c k a r d t s c o r e r e d u c e d significantly(pre-operation vs post-operation:8.0 vs 1.0,P 0.05). Median LES pressure decreased from 27.4 to 9.6 mm Hg(P 0.05). Median diameter of the esophagus was significantly decreased(pre-operation vs post-operation:51.0 mm vs 30.0 mm,P 0.05). Only one patient had reflux,which was resolved with oral proton pump inhibitors. No serious complications related to POEM were found. The quality of life of the 15 patients improved significantly after ***:POEM is a safe and effective technique for treatment of achalasia in patients aged ≥ 65 years,with improvement in symptoms and quality of life.