Establishing a Multifaceted Comprehensive Maternity Cohort Facilitates Understanding of How Environmental Exposures Impact Perinatal Health
作者机构：Centre for Sustainable MedicineYong Loo Lin School of MedicineNational University of SingaporeSingapore 117609Republic of Singapore Department of PaediatricsYong Loo Lin School of Medicine and Saw Swee Hock School of Public HealthNational University of SingaporeSingapore 117609Republic of Singapore Department of ObstetricsWomen’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006PR China Yusuf Hamied Department of ChemistryUniversity of CambridgeCambridge CB21EWUnited Kingdom Department of Earth SciencesUniversity of CambridgeCambridge CB23EQUnited Kingdom Department of Obstetrics and GynecologyThe Fourth Affiliated HospitalZhejiang University School of MedicineYiwuZhejiang 322000PR China Wenling Women’s and Children’s HospitalTaizhouZhejiang 317500PR China Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang ProvinceCollege of EnvironmentZhejiang University of TechnologyHangzhouZhejiang 310032PR China Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang ProvinceInterdisciplinary Research AcademyZhejiang Shuren UniversityHangzhouZhejiang 310006PR China Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive HealthSchool of Public HealthPeking University Health Science CentreBeijing 100191PR China Vanke School of Public HealthTsinghua UniversityBeijing 100084PR China Department of PaediatricsYong Loo Lin School of MedicineNational University of SingaporeSingapore 117609Republic of Singapore Department of PaediatricsYong Loo Lin School of Medicine and Human Potential Translational Research ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore 117609Republic of Singapore Singapore Institute for Clinical Sciences(SICS)Agency for ScienceTechnology and Research(A^(*)STAR)Singapore 117609Republic of Singapore School of Public Health and Preventive MedicineMonash UniversityMelbourneVictoria 3004Australia Maternal and Child Health DivisionHealth Commission of Zhejiang ProvinceHangzhouZhejiang 310006PR China Key Laboratory of Women’s Reproductive HealthHangzhouZhejiang 310006PR China
出 版 物：《Environment & Health》 (环境与健康（英文）)
年 卷 期：2024年第2卷第11期
页 面：766-775页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：funding from various sources,including the Zhejiang Province Health Innovative Talent Project(A0466) the International Cooperation Seed Program of Women’s Hospital,Zhejiang University(GH2022B008-01 and GH2024005) the Australian Research Council(DP210102076) the Australian National Health and Medical Research Council(APP2000581) the UK Research and Innovation(UKRI)Centre for Application of Artificial Intelligence to the Study of Environmental Risks(AI4ER,EP/S022961/1) the Start-up Grant from Yong Loo Lin School of Medicine,National University of Singapore(NUHSRO/2024/045/Startup/06),and the US-China Fulbright Program
主 题：cohort profile prospective maternity cohort perinatal health pre-eclampsia preterm birth low birth weight environmental exposure
摘 要：China’s“three-child policy,implemented in response to population aging,has made the protection of maternal and infant health an urgent *** this environmental and medical big-data era,the Zhejiang Environmental and Birth Health Research Alliance(ZEBRA)maternity cohort was established with the aim of identifying risk factors for perinatal morbidity and mortality from the perspectives of both observational epidemiology and experimental *** with conventional birth cohorts,the inclusion of a maternity cohort allows greater scope for research and places an emphasis on maternal *** particular,it allows us to focus on pregnant women with a history of pregnancy-related illnesses and those planning to have a second or third *** are currently many pressing issues in perinatal health,including the risk associations between exogenous together with endogenous factors and the occurrence of perinatal abnormalities,pregnancy complications,and adverse pregnancy *** is crucial to explore the interaction between environmental exposures and genetic factors affecting perinatal health if we are to improve *** is also worthwhile to assess the feasibility of the early stage prediction of major perinatal *** hope to study this in the ZEBRA cohort and also seek nationwide and international collaborations to establish a multicenter cohort consortium,with the ultimate goal of contributing epidemiological evidence to literature and providing evidence-based insights for global maternal and child healthcare.
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