Changes in interleukin-6 levels in saliva in patients with oral squamous cell carcinoma during the treatment phase.

作     者：Jun Goto Ayako Harahashi Yutaka Yamazaki Akira Satoh Yoshimasa Kitagawa 

作者机构：Oral Diagnosis and Medicine Department of OralPathobiological Science Hokkaido University Graduate Schoolof Dental Medicine. Sapporo Japan 

出 版 物：《中国口腔颌面外科杂志》 (China Journal of Oral and Maxillofacial Surgery)

年 卷 期：2008年第6卷第B5期

页      面：150-151页

学科分类：1003[医学-口腔医学] 1002[医学-临床医学] 100301[医学-口腔基础医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：口腔 鳞状细胞癌 治疗方法 临床分析 

摘      要：Purpose: To compare interleukin-6 (IL-6) levels between patients with oral squamous cell carcinoma (OSCC) and controls, and to elucidate the changes in IL-6 levels during the treatment phase。Methods: Twenty-nine consecutive subjects with OSCC were enrolled in this study。The patients were guided for systematic oral care just after admission to prevent complications such as pneumonia。Saliva was collected three times during the treatment phases in the patient group。As controls, 11 healthy volunteers were recruited。Results: IL-6 was detected in 22/28 samples in the patient group at the time of admission。The median concentration of IL-6 was significantly higher in the patient group (3.6 pg/ml) than in the controls (0.4 pg/ml) (P=0.03)。Just before the surgery, the median concentration of IL-6 was 4.8 pg/ml, which was significantly higher than that at the time of admission (P=0.01)。The median concentration of IL-6 was 5.2 pg/ml at the time of discharge。Conclusion: IL-6 was up-regulated in saliva in the OSCC patients。IL-6 level tended to increase before treatment, and was not reduced significantly at discharge。IL-6 in saliva may contribute to the immune response or progression of OSCC。