Synthesis of 4-（4-Methylsulfonylphenyl）-3-phenyl-2（3H）-thiazole Thione Derivatives as New Potential COX-2 Inhibitors

作     者：EMAMI, Saeed FOROUMADI, Alireza 

作者机构：Department of Medicinal Chemistry Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Iran Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Tehran Iran 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2006年第24卷第6期

页      面：791-794页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：synthesis diaryl heterocycle 2(3H)-thiazole thione COX-2 inhibitor 

摘      要：Synthesis of novel 4-（4-methylsulfonylphenyl）-3-phenyl-2（3H）-thiazole thione derivatives with functionalized diarylheterocycle pharmacophore as potential COX-2 inhibitors was described. The title compounds were synthesized by cyclocondensation of corresponding dithiocarbamate and 2-bromo-1-（4-methylsulfonylphenyl）ethanone, followed by dehydration with H2SO4. All of the target compounds were characterized by ^1H NMR, IR and mass spectral data.