Protective effect of Wnt-5a against amyloid beta-induced memory impairment in rats

作     者：Guili Zhang Lu Lu Yaping Ge Fang Deng Ying Zhang Jiachun Feng 

作者机构：Department of Neurology First Affiliated Hospital Jilin University Changchun 130021 Jilin Province China Department of Mammary Glands First Affiliated Hospital Jilin University Changchun 130021 Jilin Province China Department of Ophthalmology Jilin Province People's Hospital Changchun 130021 Jilin Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第14期

页      面：1052-1056页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071009[理学-细胞生物学] 09[农学] 071006[理学-神经生物学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：Wnt-5a Alzheimer's disease N-methyI-D-aspartate receptor cognition amyloid β protein 

摘      要：Recent studies suggest that the activation of the Wnt signaling pathway improves memory function in *** study investigated the effects of Wnt-5a on amyloid β （Aβ）-induced cognitive impairment.Aβ25-35 was injected into the rat right lateral ventricle to induce Alzheimer＇s disease-associated pathology,and Wnt-5a was injected as a potential therapeutic *** staining showed that compared with normal rats,Aβ25-35 significantly decreased postsynaptic density-95 protein expression in the rat hippocampal CA1 region,but Wnt-5a pretreatment blocked this *** study shows that Wnt-5a can reduce Aβ-induced cognitive impairment,and that it has the potential to be a new therapeutic strategy for the treatment of Alzheimer＇s disease.