miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas

作     者：Dong Ho Choi Sang Jae Park Hark Kyun Kim 

作者机构：Department of Surgery Hanyang University School of Medicine Center for Liver CancerNational Cancer Center Biomolecular Function Research BranchNational Cancer Center 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2015年第14卷第3期

页      面：325-329页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Proteogenomic Research Program through the National Research Foundation of Korea the Converging Research Center Program(2013K000429)funded by the Korean Ministry of Science,ICT,and Future Planning 

主　　题：ampulla of Vater pancreatic cancer gene expression 

摘      要：Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pan- creatic carcinomas using microarrays, miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampuUary carcinomas than in pancreatic carcino- mas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory mi- croRNAs warrant future validation.