Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis

作     者：Yue Zhou Zi Wang Shen Ren Wei Li Yue Zhou;Zi Wang;Shen Ren;Wei Li

作者机构：College of Chinese Medicinal MaterialsJilin Agricultural UniversityChangchun 130118China College of Life SciencesJilin Agricultural UniversityChangchun 130118China 

出 版 物：《Chinese Herbal Medicines》 (中草药（英文版）)

年 卷 期：2024年第16卷第4期

页      面：548-557页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the grants of National Natural Science Foundation of China (No. 82104465) Changchun Science & Technology Development Plan (No. 21ZGY11) the Scientific Research Planning Project of Jilin Provincial Department of Education (No. JJKH20220371KJ) 

主　　题：anti-hepatocellular carcinoma ginsenoside Rb_(1) ginsenoside Rd ginsenoside Rg_(3) ginsenoside Rg_5 ginsenoside Rh_(2) ginsenoside Rk_(1) network pharmacology protopanaxadiol ginsenosides 

摘      要：Hepatocellular carcinoma(HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides(PDs) have been believed to significantly improve liver diseases. PDs, such as Rg_(3), have been developed as a new class of anti-cancer *** Rb_(1), Rd, Rg_(3), and Rh_(2) exhibit effective anti-inflammatory and anti-tumor *** have confirmed that PDs could be used to treat HCC. However, the mechanism of action of PDs on HCC remains unclear. In the study, we reviewed the anti-HCC effects and mechanisms of PDs including Rb_(1), Rd, Rg_(3), Rg_5, Rh_(2), Rk_(1), and Compound K(CK). Then, we searched for relevant targets of PDs and HCC from databases and enriched them for analysis. Subsequently, molecular docking was simulated to reveal molecular mechanisms. We found that PDs may treat HCC through multiple signaling pathways and related targets. PDs could inhibit the proliferation, invasion, and metastasis of HCC while promoting apoptosis and inducing differentiation. In conclusion, this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms. These insights will aid in the direction of further pharmacological studies and the development of safe and effective clinical drugs.