Intensive care unit-acquired weakness–preventive,and therapeutic aspects;future directions and special focus on lung transplantation

作     者：Thirugnanasambandan Sunder 

作者机构：Department of Heart Lung Transplantation and Mechanical Circulatory SupportApollo HospitalsChennai 600086Tamil NaduIndia 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第19期

页      面：3665-3670页

学科分类：1011[医学-护理学（可授医学、理学学位）] 10[医学] 

主　　题：Intensive care unit-acquired weakness Critical illness myopathy Critical illness polyneuropathy Critical illness polyneuromyopathy Early mobilization Prolonged ventilation Nutritional rehabilitation Lung transplantation 

摘      要：In this editorial,comments are made on an interesting article in the recent issue of the World Journal of Clinical Cases by Wang and *** authors describe the use of neural network model to identify risk factors for the development of intensive care unit(ICU)-acquired *** condition has now become common with an increasing number of patients treated in ICUs and continues to be a source of morbidity and *** identification of certain risk factors and corrective measures thereof,lacunae still exist in our understanding of this clinical *** possible pathogenetic mechanisms at a molecular level have been described and these continue to be *** amount of retrievable data for analysis from the ICU patients for study can be huge and *** learning techniques to identify patterns in vast amounts of data are well known and may well provide pointers to bridge the knowledge gap in this *** editorial discusses the current knowledge of the condition including pathogenesis,diagnosis,risk factors,preventive measures,and ***,it looks specifically at ICU acquired weakness in recipients of lung transplantation,because–unlike other solid organ transplants-muscular strength plays a vital role in the preservation and survival of the transplanted *** differ from other solid organ transplants in that the proper function of the allograft is dependent on muscle *** weakness especially diaphragmatic weakness may lead to prolonged ventilation which has deleterious effects on the transplanted lung–ranging from ventilator associated pneumonia to bronchial anastomotic complications due to prolonged positive pressure on the anastomosis.