PLA2G2D and CHIT1: Potential biomarkers for immune infiltration and prognosis in cervical squamous cell carcinoma
作者机构：Department of Gynecological TumorHarbin Medical University Cancer HospitalHarbin 150001China Department of PathologyHarbin Medical University Cancer HospitalHarbin 150001China
出 版 物：《Frigid Zone Medicine》 (寒地医学（英文）)
年 卷 期：2024年第4卷第2期
页 面：110-119页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the Haiyan Foundation Youth Project JJQN2022-12
主 题：cervical cancer immune cells overall survival immune score genes
摘 要：Objective:The aim of this study was to identify biomarkers associated with immunity and prognosis in patients with cervical *** and methods:Data from patients with cervical squamous cell carcinoma(CESC)were retrieved from the UCSC Xena database and subjected to *** sets representing 22 types of immunocytes were acquired,and immunocytes relevant to prognosis were *** gene co-expression network analysis(WGCNA)was utilized to identify gene modules associated with prognosis-related immunocytes and to construct immune-related gene *** expressed genes were then screened,and the association between immune score and biological function of immune-related gene markers was ***,tissue samples from cervical cancer patients in Northeast China were collected to validate the expression of two genes using real-time PCR and ***:This study identified 10 immunocytes significantly correlated with overall survival time in *** gene modules were identified as significantly associated with prognosis-related immunocytes,with gene module 6 showing relevance to all prognosis-related *** module 6 was related to all prognosis-related ***,two genes(including PLA2G2D and CHIT1)were found to be significantly associated with overall survival in cancer *** with CESC were classified into high and low immune score groups based on the median score of gene *** analysis of the immune score and biological function was *** and real-time PCR results revealed high expression of CHIT1 and PLA2G2D in CESC tumor ***:PLA2G2D and CHIT1 show promise as biomarkers for evaluating immune infiltration and prognosis in patients with cervical cancer.
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