ZIP4 inhibits Ephrin-B1 ubiquitination,activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis

作     者：Haijun Guo Renyi Su Xinfeng Lu Hui Zhang Xuyong Wei Xiao Xu 

作者机构：Department of Hepatobiliary and Pancreatic SurgeryAffiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Zhejiang University School of MedicineHangzhouZhejiang 310058China The Fourth School of Clinical MedicineZhejiang Chinese Medicine UniversityHangzhouZhejiang 310053China School of Clinical MedicineHangzhou Medical CollegeHangzhouZhejiang 310014China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第6期

页      面：1-4页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Zhejiang Provincial Natural Science Foundation of China (No.LQ20H160029) The Construction Fund of Key Medical Disciplines of Hangzhou,Zhejiang,China (No.0020200093) The Major Research Plan of the National Natural Science Foundation of China (No.92159202) The Key Program,National Natural Science Foundation of China (No.81930016) The Key Research&Development Plan of Zhejiang Province,China (No.2019C03050) 

主　　题：ZEB1 metastasis cancer 

摘      要：Hepatocellular carcinoma(HCC),a highly malignant tumor,faces a major challenge with its high post-hepatectomy recurrence impacting patient *** and preventive strategies remain to be ***-/lrt-like protein 4(ZIP4,also called SLC39A4/solute carrier family 39 member 4)belongs to the zinc transporter ZiP superfamily of which the members play an important role in maintaining zinc steady state,and its high expression in various tumors is associated with the prognosis of cancer patients.