Solute clearance effect of citrate anticoagulation hemodialysate for hemodialysis in patients with high risk of bleeding

作     者：赵光本 桂保松 于长青 薛静 孙宏艳 

作者机构：Department of Nephrology the Second Hospital Medical School of Xi'an Jiaotong University Department of Nephrology of the first Affiliated Hospital Dalian Medical University Department of General Surgery Chinese PLA 323 Hospital 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2008年第20卷第4期

页      面：225-227,245页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 

基　　金：supported by the Scientific Research Fund of Shaanxi Province (No.2001K10-G2-4) 

主　　题：citrate dialysate anticoagulation hemodialysis 

摘      要：Objective To study the solute clearance effect of the new concentrated anticoagulation hemodialysate of citrate for hemodialysis in patients with high risk of bleeding. Methods Forty-two kidney failure patients with high risk of bleeding were divided into two groups (Group A and Group B) according to their hemodialysis manners. Patients in Group A were hemodialyzed with bicarbonate hemodialysate with low-molecular-weight heparin (dalteparin) anticoagulation and those in Group B with the new citrate anticoagulation hemodialysate prepared in our hospital without any other anticoagulant. Blood urea nitrogen (BUN) and creatinine (Cr) concentrations were measured before and after dialysis, and Kt/V and urea reduction rate (URR) were calculated. In addition, activated clotting time (ACT) and ionized calcium (iCa2+) concentration were also measured at the arterial and venous ends. Results ACT was extended and iCa2+ concentration decreased significantly at the venous end compared with those at the arterial end in Group B (P0.05). Conclusion The solute clearance effect of the new concentrated anticoagulation hemodialysate of citrate is excellent during hemodialysis in kidney failure patients with high risk of bleeding.