Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma

作     者：Li, Lan Shi, Yong-Hong Guo, Zhi-Juan Qiu, Tian Guo, Lei Yang, Hong-Ying Zhang, Xun Zhao, Xin-Ming Su, Qin 

作者机构：Chinese Acad Med Sci Inst Canc Dept Pathol Beijing 100021 Peoples R China Chinese Acad Med Sci Canc Hosp Dept Pathol Beijing 100021 Peoples R China Peking Union Med Coll Beijing 100021 Peoples R China Inner Mongolia Med Coll Affiliated Hosp 1 Dept Pathol Hohhot 010059 Inner Mongolia Peoples R China Inner Mongolia Med Coll Renmin Hosp Dept Pathol Hohhot 010059 Inner Mongolia Peoples R China Chinese Acad Med Sci Inst Canc Dept Radiol Beijing 100021 Peoples R China Chinese Acad Med Sci Canc Hosp Dept Radiol Beijing 100021 Peoples R China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第20期

页      面：2504-2519页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grants from National Natural Science Foundation of China No.30171052 30572125 and 30772508 

主　　题：Extranodal follicular dendritic cell sarcoma Prognosis assessment Histologic grade Immunohistochemistry In situ hybridization Mutation detection 

摘      要：AIM: To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) ***: Nine lesions were examined by routine and molecular *** factors from the new cases and 97 reported cases were analyzed for their prognostic ***: The current lesions were found in f ive male and four female patients,located mainly in the head and neck area and averaging 7.2 cm in *** patients had recurrence or metastasis and three remained free of *** 106 patients (male/female ratio,1.1:1) were aged from 9 to 82 years (median,44 years).The tumor sizes ranged from 1.5 to 21 cm (mean,7.4 cm).Abdominal/pelvic region was affected most frequently (43%).Surgical resection was performed in 100 patients,followed by radiation and/or chemotherapy in 35 of ***-up data were available in 91 cases,covering a period of 3-324 mo (mean,27 mo;median,19 mo).Of the informative cases,38 (42%) had recurrence or metastasis,and 12 (13%) died of the *** tumors were classif ied histologically into lowand high-grade lesions.A size ≥ 5 cm (P = 0.003),highgrade histology (P = 0.046) and a mitotic count ≥ 5/10 HPF (P = 0.013) were associated with tumor *** lesions were def ined as low-,intermediateand high-risk tumors,and their recurrence rates were 16%,46% and 73%,and their mortality rates 0%,4% and 45%,***: Extranodal FDC tumors behave like soft tissue *** clinical outcomes are variable and can be evaluated according to their sizes and grades.