Targeting brain-derived neurotrophic factor in the treatment of neurodegenerative diseases:A review
Targeting brain-derived neurotrophic factor in the treatment of neurodegenerative diseases: A review作者机构：The Postgraduate Training Base of Jinzhou Medical University(The PLA Rocket Force Characteristic Medical Center)BeijingChina Department of AnesthesiologyThe PLA Rocket Force Characteristic Medical CenterBeijingChina
出 版 物：《Neuroprotection》 (神经保护（英文）)
年 卷 期：2024年第2卷第2期
页 面：67-78页
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：National Natural Science Foundationof China Grant/AwardNumber:82171203
主 题：brain-derived neurotrophic factor central nervous system drug therapy gene therapy neurodegenerative diseases neuron
摘 要：Neurodegenerative diseases,marked by the gradual death of neurons,present a significant and growing public health ***-derived neurotrophic factor(BDNF)is crucial for the survival,development,and synaptic plasticity of *** have consistently demonstrated that perturbed BDNF communication pathways are associated with the development and progression of neurodegenerative conditions,underscoring their potential as therapeutic *** review aimed to summarize the existing findings regarding BDNF expression,metabolism,and signaling ***,we reviewed the intricate roles of BDNF signaling pathways in neurodegenerative diseases,elucidating their contributions to disease onset and *** latest advancements in targeting BDNF for the treatment of neurodegenerative diseases,including the development of small molecules,nucleic acid-based therapeutics,and antibody-based approaches,were also *** recent strides,challenges persist,including a lack of comprehensive understanding of BDNF modulation across diverse neurodegenerative contexts and the absence of clinically approved BDNF-targeted drugs.
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