Role of short-chain fatty acids in host physiology

作     者：Mingyue Liu Yubo Lu Guoyu Xue Le Han Hanbing Jia Zi Wang Jia Zhang Peng Liu Chaojuan Yang Yingjie Zhou Mingyue Liu;Yubo Lu;Guoyu Xue;Le Han;Hanbing Jia;Zi Wang;Jia Zhang;Peng Liu;Chaojuan Yang;Yingjie Zhou

作者机构：Stem Cell Storage CenterHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiChina Prevention Health SectionHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina Department of Medical ImagingHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina Department of ObstetricalHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina Department of Clinical LaboratoryHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Engineering MedicineBeihang UniversityBeijingChina Department of Obstetrics and GynecologyHebei Reproductive Health HospitalHebei Women and Children's Health HospitalHebei Research Institute For Reproductive HealthShijiazhuangChina 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2024年第7卷第5期

页      面：641-652页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Hebei Medical Science Research Project(20242002) S&T Program of Hebei(21377722D) the National Natural Science Foundation of China(82001145) 

主　　题：gut microbiota host i nteraction relationship short-chain fatty acids 

摘      要：Short-chain fatty acids(SCFAs)are major metabolites produced by the gut microbiota through the fermentation of dietary fiber,and they have garnered significant attention due to their close association with host *** important mediators between the gut microbiota and the host,SCFAs serve as energy substrates for intestinal epithelial cells and maintain homeostasis in host immune and energy metabolism by influencing host epigenetics,activating G protein-coupled receptors,and inhibiting pathogenic microbial *** review provides a comprehensive summary of SCFAs synthesis and metabolism and offering an overview of the latest research progress on their roles in protecting gut health,enhancing energy metabolism,mitigating diseases such as cancer,obesity,and diabetes,modulating the gut-brain axis and gut-l ung axis,and promoting bone health.