Exosome-biomimetic nanocarriers for oral drug delivery

作     者：Fengjie Liu Fansu Meng Zhenjiang Yang Huan Wang Yuehong Ren Yu Cai Xingwang Zhang 

作者机构：Department of PharmaceuticsCollege of PharmacyJinan UniversityGuangzhou 511443China Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of TCMZhongshan 528400China Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033China State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第9期

页      面：65-71页

核心收录：

学科分类：1002[医学-临床医学] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Guangdong Basic and Applied Basic Research Foundation(No.2023A1515012326) Major International(Regional)Joint Research Project of National Natural Science Foundation of China(No.82020108033) Science and Technology Projects in Guangzhou(No.202103000091) Sanming Project of Medicine in Shenzhen(No.202211003) 

主　　题：Exosomes Oral delivery Biomimetic nanocarriers Targeting Bioavailability 

摘      要：Exosomes as authigenous nanovesicles secreted by living cells represent a significant class of *** virtue of their unique roles in intercellular communication,exosomes can mediate intercellular information/cargoes exchange as messenger and facilitate drug delivery as smart *** medication is the most clinically relied upon route of administration and can achieve both topical and systemic therapeutic effects after *** and exosome-derived vectors have shown to be of high value in oral drug delivery,since they enable efficient oral delivery of therapeutic molecules by targeting intestinal epithelial *** recent years,exosome-biomimetic nanocarriers have emerged as an important catalyzer in innovating oral drug delivery *** this work,we roundly reviewed the biogenesis and functions of exosomes,their extraction and characterization methods,resources available for exosomes harvest,and design philosophy of exosome-derived vehicles,particularly highlighting the oral delivery application of exosome-biomimetic nanocarriers for diverse *** evidence suggests that exosome-biomimetic nanocarriers hold great promise for oral delivery of intractable drugs with potential biopharmaceutic issues.