First Trimester Preeclampsia Screening and Prevention:Perspective in Chinese Mainland

作     者：Jiao Liu Yunyu Chen Sin Ting Tai Long Nguyen-Hoang Kunping Li Jing Lin Xiaohong Lu Liona C.Poon Jiao Liu;Yunyu Chen;Sin Ting Tai;Long Nguyen-Hoang;Kunping Li;Jing Lin;Xiaohong Lu;Liona C. Poon

作者机构：Department of Obstetrics and GynecologyThe Chinese University of Hong KongShatinHong Kong 999077China. 

出 版 物：《Maternal-Fetal Medicine》 (母胎医学杂志（英文）)

年 卷 期：2024年第6卷第2期

页      面：84-91页

核心收录：

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：the National Key Research and Development Program of China(No.2021YFC2701600 and 2021YFC2701604). 

主　　题：Preeclampsia Chinese population First trimester Screening Prevention 

摘      要：Preeclampsia(PE),a multisystem disorder in pregnancy,is one of the leading causes of perinatal morbidity and mortality that poses financial and physical burdens worldwide.Preterm PE with delivery at37 weeks of gestation is associated with a higher risk of adverse maternal and perinatal outcomes than term PE with delivery at≥37 weeks of gestation.A myriad of first trimester screening models have been developed to identifying women at risk of preterm PE.In fact,the Fetal Medicine Foundation(FMF)first trimester prediction model has undergone successful internal and external validation.The FMF triple test enables the estimation of patient-specific risks,using Bayes theorem to combine maternal characteristics and medical history together with measurements of mean arterial pressure,uterine artery pulsatility index,and serum placental growth factor.Establishing a quality control process for regular monitoring and to ensure data standardization,reliability,and accuracy is key to maintaining optimal screening performance.The rate of preterm PE can be reduced by 62%by using the FMF prediction model,followed by the administration of low-dose aspirin.Recent evidence has also demonstrated that metformin has the potential for preventing PE in patients at high-risk of the disorder.In this article,we will summarize the existing literature on the different screening methods,different components of risk assessment,therapeutic interventions,and clinical implementation of the first trimester screening and prevention program for PE with specific considerations for Chinese mainland.