Stereochemical editing:Catalytic racemization of secondary alcohols and amines

作     者：Jun Zhang Zhiyao Zheng Can Zhu Jun Zhang;Zhiyao Zheng;Can Zhu

作者机构：Department of ChemistryFudan UniversityShanghai 200438China Department of Organic ChemistryArrhenius LaboratoryStockholm UniversityStockholm 10691Sweden 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第5期

页      面：17-31页

核心收录：

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China (No. 22271054) the “1000-Youth Talents Plan” Fudan University (start-up grant) for financial support. 

主　　题：Racemization Secondary alcohols Amines Kinetic resolution Dynamic kinetic resolution 

摘      要：Chiral alcohols and amines are important structural units widely existing in pharmaceuticals,agrochemicals,and food additives.Dynamic kinetic resolution(DKR)is an efficient strategy to deliver optically active alcohols and amines from their racemates.For the development of DKR method,racemization catalyst plays as a crucial element with the requirement of compatibility with the kinetic resolution(KR)system.In this paper,recent advance in the catalytic racemization of secondary alcohols and amines is summarized based on different types of racemizing intermediates,which are redox racemization via ketone/imine intermediates,racemization via radical intermediates,and racemization via carbocation intermediates.Enzymatic racemization of secondary alcohols and amines is also enclosed.