Oxygen vacancy boosting Fenton reaction in bone scaffold towards fighting bacterial infection

作     者：Cijun Shuai Xiaoxin Shi Feng Yang Haifeng Tian Pei Feng Cijun Shuai;Xiaoxin Shi;Feng Yang;Haifeng Tian;Pei Feng

作者机构：State Key Laboratory of Precision Manufacturing for Extreme Service PerformanceCollege of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083People’s Republic of China Institute of Additive ManufacturingJiangxi University of Science and TechnologyNanchang 330013People’s Republic of China College of Mechanical EngineeringXinjiang UniversityUrumqi 830017People’s Republic of China 

出 版 物：《International Journal of Extreme Manufacturing》 (极端制造（英文）)

年 卷 期：2024年第6卷第1期

页      面：296-311页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 0703[理学-化学] 

基　　金：supported by the following funds:The Natural Science Foundation of China(52275393,51935014,82072084) Hunan Provincial Natural Science Foundation of China(2021JJ20061) Jiangxi Provincial Natural Science Foundation of China(20224ACB204013) The Project of State Key Laboratory of Precision Manufacturing for Extreme Service Performance Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020(PT2020E002) Guangdong Province Precision Manufacturing and Intelligent production education Integration Innovation Platform(2022CJPT019) Independent Exploration and Innovation Project of Central South University(1053320220553)。 

主　　题：bacterial infection bone scaffold selective laser sintering Fenton reaction antibacterial properties 

摘      要：Bacterial infection is a major issue after artificial bone transplantation due to the absence of antibacterial function of bone scaffold,which seriously causes the transplant failure and even amputation in severe cases.In this study,oxygen vacancy(OV)defects Fe-doped Ti O2(OV-FeTiO2)nanoparticles were synthesized by nano TiO2and Fe3O4via high-energy ball milling,which was then incorporated into polycaprolactone/polyglycolic acid(PCLGA)biodegradable polymer matrix to construct composite bone scaffold with good antibacterial activities by selective laser sintering.The results indicated that OV defects were introduced into the core/shell-structured OV-FeTiO2nanoparticles through multiple welding and breaking during the high-energy ball milling,which facilitated the adsorption of hydrogen peroxide(H2O2)in the bacterial infection microenvironment at the bone transplant site.The accumulated H2O2could amplify the Fenton reaction efficiency to induce more hydroxyl radicals(·OH),thereby resulting in more bacterial deaths through·OH-mediated oxidative damage.This antibacterial strategy had more effective broad-spectrum antibacterial properties against Gram-negative Escherichia coli(E.coli)and Gram-positive Staphylococcus aureus(S.aureus).In addition,the PCLGA/OV-FeTiO2scaffold possessed mechanical properties that match those of human cancellous bone and good biocompatibility including cell attachment,proliferation and osteogenic differentiation.