Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

作     者：ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie 

作者机构：College of Integrated Traditional Chinese and Western MedicineHebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicinethe Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate SchoolHebei Medical UniversityShijiazhuang 050017China Rural Physician CollegeHebei Medical UniversityShijazhuang 050017China Medical Departmentthe First Hospital of Hebei Medical UniversityShijiazhuang 050030China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2024年第30卷第5期

页      面：468-479页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Supported by the Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine (No.2020149)。 

主　　题：pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms 

摘      要：Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and hypertension.Noncoding RNAs(nc RNAs)are important regulatory factors.Many Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting effects.The mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator 1.The NLRP3 protein is an important regulatory target for CVD prevention and treatment with CM.Exploring the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.