Molecular cascades and cell type-specific signatures in ASD revealed by single-cell genomics

作     者：Brie Wamsley 

作者机构：不详 

出 版 物：《四川生理科学杂志》 (Sichuan Journal of Physiological Sciences)

年 卷 期：2024年第46卷第5期

页      面：993-993页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：signature ASD Molecular 

摘      要：Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular *** drives these changes and how they relate to genetic susceptibility in this complex condition are not well *** performed deep single-nucleus RNA sequencing(snRNA-seq)to examine cell composition and transcriptomics,identifying dysregulation of cell type-specific gene regulatory networks(GRNs)in autism spectrum disorder(ASD).