Nuclear transport receptors underpin plastidial retrograde signaling

作     者：Min Jia Yangnan Gu Min Jia;Yangnan Gu

作者机构：Department of Plant and Microbial BiologyUniversity of CaliforniaBerkeleyBerkeleyCAUSA 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2024年第17卷第7期

页      面：993-995页

核心收录：

学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学] 

基　　金：the USDA National Institute of Food and Agriculture(HATCH project CA-B-PLB-0243-H) US National Science Foundation(MCB-2049931) 

主　　题：complex. integrate ternary 

摘      要：The nucleus integrates cytosolic and organellar signals to regulate gene expression during plant stress responses,and this process is highly dependent on shuttling of signaling molecules in and out of the *** nucleocytoplasmic transport of macromolecules is facilitated by nuclear transport receptors(NTRs).NTRs are broadly categorized into exportins,which mediate the export of cargo from the nucleus to the cytoplasm,and importins,which facilitate the import of cargo into the *** importin family comprises importin-α(IMPa)and importin-β(IMPp).IMPa proteins are adaptor proteins and composed of three functional domains:an N-terminal IMPβ-binding(IBB)domain,ten Armadillo(ARM)repeats responsible for recognizing and interacting with cargo,and an exportin-interacting domain crucial for recycling via nuclear export(Wing et al.,2022).During a nuclear transport event,*** cargo containing a classical nuclear localization signal(cNLS)through its ARM repeats and engages IMPβvia its IBB domain,forming the cargo-IMPa-IMPβternary ***βfacilitates translocation of this complex through the nuclear *** inside the nucleus,RanGTP competes with IMPa for binding to IMPβ,promoting disassembly of the transport complex and releaseofcargo.