Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

作     者：Ben Hu Hua Guo Haorui Si Zhengli Shi Ben Hu;Hua Guo;Haorui Si;Zhengli Shi

作者机构：CAS Key Laboratory of Special Pathogens and BiosafetyWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of SciencesBeijing100049China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2024年第18卷第1期

页      面：1-18页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(Nos.2022YFC2305101 and 2021YFC0863400) the Strategic Research and Consulting Program of Chinese Academy of Engineering(No.2022-JB-06-04). 

主　　题：SARS COVID-19 coronavirus 

摘      要：Severe acute respiratory syndrome(SARS)and Coronavirus disease 2019(COVID-19)are two human Coronavirus diseases emerging in this century,posing tremendous threats to public health and causing great loss to lives and economy.In this review,we retrospect the studies tracing the molecular evolution of SARS-CoV,and we sort out current research findings about the potential ancestor of SARS-CoV-2.Updated knowledge about SARS-CoV-2-like viruses found in wildlife,the animal susceptibility to SARS-CoV-2,as well as the interspecies transmission risk of SARS-related coronaviruses(SARSr-CoVs)are gathered here.Finally,we discuss the strategies of how to be prepared against future outbreaks of emerging or re-emerging coronaviruses.