Characterization of CD4~+ T Cell Responses in Mice Infected with Schistosoma japonicum
Characterization of CD4~+ T Cell Responses in Mice Infected with Schistosoma japonicum作者机构：DepartmentofPathogenBiologyNanjingMedicalUniversityNanfing210029China
出 版 物：《Acta Biochimica et Biophysica Sinica》 (生物化学与生物物理学报(英文版))
年 卷 期：2006年第38卷第5期
页 面：327-334页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 100103[医学-病原生物学] 0703[理学-化学] 10[医学]
主 题：Schistosoma japonicum CD4~+ T cell immune deviation immune regulatory network
摘 要：To better understand the interaction between Schistosoma japonicum and its murine host,wecharacterized the immune response of CD4~+ T cells generated during an experimental *** infectionbased on different key aspects,from gene expression to cell *** oligonucleotide microarrayswere used to compare gene expression profiles of CD4~+ T cells from spleens of mice at 0,3,6 and 13weeks *** cytometry analysis was used to determine type 1 and type 2 cytokine-secretingCD4~+ T cells,to test apoptosis of CD4~+ T cells and to count CD4~+CD25~+ T cells,a kind of regulatorysubpopulation of CD4~+ T *** percentage of interleukin-4-producing CD4~+ T cells was found to bemuch higher than that of γ-interferon-producing cells,especially after stimulation with *** eggantigen,which was consistent with type 1 and type 2 cytokine gene expression in the *** also showed that *** induced the increased expression of Th2 response-related genes,whereassome transcripts related to the Th1 responsive pathway were *** cytometry analysis showeda marked increase in the apoptotic CD4~+ T cells from 6 weeks post-infection and in the ratio of CD4~+CD25~+to CD4~+ T cells in infected mice after 13 *** therefore concluded that experimental infection of micewith *** resulted in a Th2-skewed immune response,which was to a great extent monitored bythe immune regulatory network,including cytokine cross-modulation,cell apoptosis and the subpopulationof regulatory cells.
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