Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

作     者：Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma 

作者机构：Department of Neurology and Clinical Research Center of Neurological Diseasethe Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-DiseasesSoochow UniversitySuzhouJiangsu ProvinceChina Department of NeurologyJiangnan University Medical CenterWuxiJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第1期

页      面：6-20页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,Nos.92049120 and 81870897 STI2030-Major Projects,No.2021ZD0204001 Guangdong Key Project for Development of New Tools for the Diagnosis and Treatment of Autism,No.2018B030335001 the Natural Science Foundation of Jiangsu Province,No.BK20181436 the National Major Scientific and Technological Special Project for Significant New Drug Development,No.2019ZX09301102 the Discipline Construction Program of the Second Affiliated Hospital of Soochow University,No.XKTJ-TD202003 Sino-German Cooperation Mobility Programme,No.M-0679 the Science and Technology Project of Suzhou,No.SKY2022161 Research Project of Neurological Diseases of the Second Affiliated Hospital of Soochow University Medical Center,No.ND2023A01(all to QHM)。 

主　　题：autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response 

摘      要：The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and proteostasis.In this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements.We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases.In summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.