Electroacupuncture targeting the immune system to alleviate sepsis

作     者：Mengyue Fang Yuye Lan Man Li Chennan Li Bin Xu Yan Ma Sulukkana Noiprasert Xianghong Jing Lingling Yu Mengyue Fang;Yuye Lan;Man Li;Chennan Li;Bin Xu;Yan Ma;Sulukkana Noiprasert;Xianghong Jing;Lingling Yu

作者机构：Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Integrated Acupuncture and Medicine Research of Ministry of EducationNanjing University of Chinese MedicineNanjingChina Wuhan No.1 HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Integrative MedicineMae Fah Luang UniversityChiangraiThailand Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijingChina Institute of Integrated Traditional Chinese and Western MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 

出 版 物：《Acupuncture and Herbal Medicine》 (针灸和草药（英文）)

年 卷 期：2024年第4卷第1期

页      面：56-67页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：funded by the National Key Research and Development Program(2022YFC3500704) the National Natural Science Foundation of China(82174500,82004491) 

主　　题：Cholinergic anti-inflammatory pathway Electroacupuncture Nuclear factor Kappa-B Sepsis Signal transducers and activators of transcription Vagal-adrenal axis 

摘      要：Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality ***,options for sepsis are still limited to general treatment in intensive care units(ICUs),and effective therapies that improve sepsis survival are *** disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation,susceptibility to infections,and ***,many investigators have focused on the potential benefits of immunomodulation therapy for ***(EA)has been practiced in clinics for many years and has shown advantages in treating infectious *** the last few decades,our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable *** searched the literature regarding“CNKI,Wan Fang Data,VIP Database,PubMed,and Ingenta Connectfrom 2010 to 2023,using the keywords“sepsis“septicand“electroacupunctureand 336 sources were ***,we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on *** this review,we found that EA has clinical benefits in relieving septic inflammation,improving immune function,and attenuating related multi-organ injury through several mechanisms,such as activation of the cholinergic anti-inflammatory pathway(CAP),vagaladrenal axis,inhibition of the nuclear factor Kappa-B(NF-κB)signaling pathway,signal transducers and activators of transcription(STAT)signaling pathway,and improvement of immune cell ***,EA may be a promising complementary therapy for sepsis *** also expect these data will contribute to further studies on EA in sepsis.