针刺治疗屈光参差性弱视:一项随机对照试验及其潜在起效机制

作     者：马翠 贾静 叶钰娟 孙燕 严兴科 Cui MA;Jing JIA;Yu-juan YE;Yan SUN;Xing-ke YAN

作者机构：甘肃中医药大学针灸推拿学院兰州730000 甘肃省康复中心医院兰州730000 

出 版 物：《World Journal of Acupuncture-Moxibustion》 (世界针灸杂志（英文版）)

年 卷 期：2024年第34卷第2期

页      面：147-155页

核心收录：

学科分类：1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by Provincial Key Talent Project of Gansu Province:20 National Natural Science Foundation of China:82160935,81860879 2022 Doctoral Tutor Project of Chinese Medicine First Level Discipline"Qi Huang Ying Cai"Tutor Special Fund:ZYXKBD-202208 2021 Gansu Province Higher Education Innovation Fund Project:2021A-087 Gansu University of Traditional Chinese Medicine Science Research and Innovation Fund Project:2022KCYB-8 

主　　题：Anisometropic amblyopia Acupuncture Resting-state fMRI Visual"what"pathway Amplitude of low frequency fluctuation Regional homogeneity 

摘      要：Objective:To evaluate the effect of acupuncture on anisometropic amblyopia(AA)and explore its potential mechanism for children with ***:Seventy-six children with monocular AA were randomized into a conventional treatment group and a combined treatment group of acupuncture and conventional treatment,with 38 patients in each *** the conventional treatment group,on the base of patching regimen,the red flashing,grating and visual stimulation were *** approach lasted for 5 min per session and was given once every two days,three times a week,for 4 consecutive *** the acupuncture-combined treatment group,on the base of the regimen of conventional treatment group,acupuncture was applied to Jingming(BL1),Cuanzhu(BL2),Fengchi(GB20)and Guangming(GB37),with needles retained for 20 min per session,once every two days,three times of intervention a week and for 4 consecutive *** and after treatment,the best corrected vision acuity(BCVA)was observed to evaluate the clinical effect in the two *** treatment started,15 patients with AA on left side were randomized selected from each group and the resting-state functional magnetic resonance imaging(rs-fMRI)was operated before and after ***,eight healthy children with normal visual acuity were recruited to be the normal control group and received one-time rs-fMRI *** on the activation likelihood estimation(ALE),the visualwhatpathway network was *** analyzing the amplitude of low frequency fluctuation(ALFF)and the regional homogeneity(ReHo),the differences in the regional autonomous function activities in the key brain areas of thewhatpathway were compared among the three ***:(1)Clinical effect:After treatment,BCVA was(0.6[0.5,0.6]),higher than that(0.4[0.3,0.5])before treatment,presenting the statistical difference(P0.05)in the conventional treatment *** was(0.6[0.6,0.8]),higher than that(0.4[0.4,0.5])before treatment,present