Tryptophan metabolism and piglet diarrhea: Where we stand and the challenges ahead

作     者：Xuan Zhao Jiaman Pang Wanghong Zhang Xie Peng Zhenguo Yang Guangdong Bai Yaoyao Xia Xuan Zhao;Jiaman Pang;Wanghong Zhang;Xie Peng;Zhenguo Yang;Guangdong Bai;Yaoyao Xia

作者机构：College of Animal Science and TechnologySouthwest University Yunnan Vocational College of Agriculture 

出 版 物：《Animal Nutrition》 (动物营养(英文))

年 卷 期：2024年第17卷第2期

页      面：123-133页

核心收录：

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：funded by the National Key Research & Development Program of China (2023YFF1001900) Fundamental Research Funds for the Central Universities (SWU-KR24023 and SWU-KQ23012) Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0786) 

主　　题：Tryptophan metabolism Piglet Diarrhea Intestinal microbiota Inflammatory response 

摘      要：The intestinal architecture of piglets is vulnerable to disruption during weaning transition and leads to diarrhea, frequently accompanied by inflammation and metabolic disturbances(including amino acid metabolism). Tryptophan(Trp) plays an essential role in orchestrating intestinal immune tolerance through its metabolism via the kynurenine, 5-hydroxytryptamine, or indole pathways, which could be dictated by the gut microbiota either directly or indirectly. Emerging evidence suggests a strong association between piglet diarrhea and Trp metabolism. Here we aim to summarize the intricate balance of microbiota-host crosstalk by analyzing alterations in both the host and microbial pathways of Trp and discuss how Trp metabolism may affect piglet diarrhea. Overall, this review could provide valuable insights to explore effective strategies for managing piglet diarrhea and the related challenges.